Difference between Duromine and Phentermine

What is the difference between Duromine capsules and Phentermine HCl 37.5 mg pills?

For over 50 years ago, Phentermine became the answer to the prayers of thousands of obese people. Today, multiple Phentermine-based drugs (Adipex-P, Metermine, Phentermine HCl 37.5, etc.) are available on the pharmaceutical market, produced by various pharmaceutical companies. The largest manufacturers are Teva (Phentermine HCl 37.5 mg tablets) and INova Pharmaceuticals (Duromine capsules).

People often ask what is the difference between Duromine and Phentermine, and which of them is better to use for an effective weight loss. It might seem that it is senseless to compare two anorectic drugs, which contain the same active substance. However, Duromine capsules and Phentermine HCl 37.5 mg tablets do differ in many ways.

Duromine vs Phentermine: Dosage form and presentation

Presentation is the difference between Duromine and Phentermine medications that we notice in the first place. Duromine is produced in the form of capsules, while Phentermine 37.5 mg (most frequently prescribed dosage) comes in the form of tablets. Both forms have their advantages and disadvantages.

Duromine capsules by INova Pharmaceuticals

  • Are easier to swallow.
  • Cannot be divided or crushed.
  • Duromine capsules are available in the dose of 15 mg, 30 mg, 40 mg; should not be open or chewed.
  • 15 mg capsules are grey and green; 30 mg capsules are grey and reddish brown; 40 mg capsules are grey and orange.​

Phentermine HCl 37.5 mg pills by Teva

  • May not dissolve in the stomach completely
  • Can be divided and taken in split doses.
  • Phentermine HCl 37.5 mg pills comes in a single dose (equal to 30 mg Phentermine base), which can be split.
  • White tablets with blue specks, capsule-shaped, with a groove in the midline.​

Duromine vs Phentermine: Ingredients and action duration

The main ingredient that provides the anorectic effect in both drugs is Phentermine substance. So, what is this active ingredient? It is a substance that stimulates the central nervous system and was approved by the FDA as a hunger-suppressing agent in the 60s of the 20th century. Drugs that contain this anorexigenic component are successfully used as adjuvants in weight loss programs, which comprise:

  • dieting
  • exercising
  • habitual changes
  • medical monitoring

It is important to understand that not a single Phentermine-based medicine is capable of ensuring a significant, sustainable or fast weight loss, when used alone without complying with the above-mentioned recommended measures.

However, when it comes to comparing phentermine-based drugs, produced by Teva and INova Pharmaceuticals, it is also important to take a closer look at the inactive components of these anorectics. This is due to the fact that they play a significant role in the onset and duration of the therapeutic effect provided.

While the appetite suppression is the main action of both Duromine and Phentermine, its onset and duration are conditioned by the excipients, used in these medicines:

  • Duromine as Ion-exchange resin

Ion exchange resin is a polymeric material that, when interacting with the base (Phentermine), helps control the release of the drug and allows extending it up to several hours. Due to this, Phentermine is slowly released from the capsule* and absorbed into the bloodstream evenly during the day, which ensures long lasting appetite suppression.

  • Phentermine as Hydrochloride

Hydrochloride is an acid salt, which is obtained when hydrochloric acid interacts with a base (Phentermine). This chemical reaction has been used for a long time in pharmacological industry to help turn organic bases into water-soluble acid salts. Thus, the excipient facilitates the dissolution of Phentermine 37.5 mg tablets in the gastrointestinal tract.

To sum up, Duromine capsules provide a slow and steady flux of the anorectic into the body, while Phentermine 37.5 mg pills provide the maximum drug concentration when the pill dissolves and a gradual weakening of the anorexigenic effect during the day.

Duromine as Ion-exchange resin

  • Slow release of the active substance
  • Long lasting equal appetite suppression throughout the day
  • Lower risk of severe side effects, because the dose of the drug enters the bloodstream in small even portions*​

* film coating of Duromine capsules further ensures slower release rate of the active ingredient

Phentermine as Hydrochloride

  • Fast, one-time release of the active substance
  • Appetite suppression gradually subsides during the day
  • Higher risk of severe side effects, because the entire dose gets into the bloodstream at once​

Duromine vs Phentermine: Dosages

Even though Phentermine-containing drugs are produced in various dosages, our present review covers specifically Phentermine HCl 37.5 mg tablets by Teva and 15 mg, 30 mg, and 40 mg Duromine capsules by INova Pharmaceuticals.

As it is clearly noticeable, you have a choice when you are prescribed Duromine, which is a very convenient thing, since the higher is the dose of Duromine, the stronger are the side effects.

While 15 mg Duromine capsules provide a sufficient appetite-suppressing effect in some people, others might need an increase in the dosage up to one 30 mg or 40 mg Duromine capsule per day. Even though the recommended starting dose for anti-obesity therapy is Duromine 30 mg with further dose adjustment, many doctors prefer putting their patients on 15 mg first and increase the dose with each further month of the weight loss course.

When it comes to Phentermine 37.5 mg, patients get a prescription for this dosage and have the possibility to alter their dose by splitting the pills and taking them by halves once or twice a day, or to take the 37.5 mg dose once a day.*

*Please note that splitting or opening or chewing Duromine capsules is strongly not recommended.

Duromine vs Phentermine: Dosing regimen

Usual instructions for the administration schedule of Phentermine-containing medicines include:

  1. Take one Phentermine pill* / Duromine capsule** as early in the morning, as possible, with or without a meal
  2. Avoid administration of the appetite suppressant in the second part of the day

* Some people prefer splitting Phentermine 37.5 mg pills in two and take the first half of the pill early in the morning, and the second half of the pill – closer to afternoon.
** Some people take one Duromine 15 mg capsule in the morning and one Duromine 15 mg capsule closer to the afternoon. 30 mg and 40 mg Duromine capsules should be taken no more than once a day.

Both recommendations aim mainly the possibility of reducing the risk of insomnia, which is a common side effect of both Duromine and Phentermine. At that, people themselves need to figure out what is their own perfect time to take the drug.

  • Some people find it best to set an alarm clock several hours before their usual waking time, take Duromine (with food or a glass of water) and go back to sleep for a couple more hours
  • Some people take Duromine at their usual awakening time, have breakfast and do not suffer from insomnia
  • Some people take Duromine closer to 10-11 AM to extend its effect to later in the evening

Duromine vs Phentermine: Course duration

Both appetite suppressants are prescription drugs that are designed for a limited-time use during a weight loss course. For better results, people are advised to increase their physical activity during the day, switch to small healthy meals and higher hydration, as well as avoid the consumption of alcohol-containing drinks.

Since these recommendations are quite common for any weight loss program, people often ask why they should take Duromine or Phentermine 37.5 mg, if they still need dieting and exercising. The answer is: the majority of people fail to comply with healthy nutrition rules, because they are incapable of fighting their appetite, and Phentermine-containing drugs can facilitate compliance with the restrictions.

Even though the efficacy of Duromine and Phentermine is a well-proven thing, its high risk for side effects does not allow using the drug for a long time, so the longest duration of these drugs use is 12 weeks in a row. At that, the health of people, who take them, should be carefully monitored by the prescribing physician to avoid or timely “catch” any health deterioration.

Duromine vs Phentermine: Contraindications

Due to the fact that both drugs have the same active ingredient, contraindications to their side effects are identical. It is critical that every person, who is planning on taking Duromine or Phentermine 37.5 mg, get familiarized with the list of contraindications and inform his doctor, if he has any of the mentioned conditions or takes any of the mentioned drugs.

Duromine vs Phentermine: Side effects

This is one more similarity between Duromine capsules and Phentermine 37.5 mg pills. Side effects of these appetite suppressants are the same and can differ quite a lot from person to person. Some people report no side effects at all, while in other people they get so serious that they have to stop using the drug. Before you begin taking any of these anorectics, learn the list of side effects and memorize those that require urgent medical assistance. Most commonly reported side effects are:

  • xerostomia (dry mouth)
  • insomnia
  • headaches
  • dizziness
  • nausea
  • constipation

Duromine vs Phentermine: Effects

It is quite logic that the appetite suppressant effect, provided by Duromine capsules and Phentermine HCl pills, is the same. However, the pharmaceutical forms of these anorectics determine the release rate of the active ingredient, which is extended in Duromine capsules and immediate in Phentermine HCl 37.5 mg pills.

In addition to the appetite suppression, both Duromine and Phentermine provide a thermogenic effect, which means that they make your body produce more energy from the fat cells. This promotes breakdown of the stored fat and boosts the weight loss results.

People often believe that Phentermine-containing medicines, while being amphetamines, are capable of providing them with euphoria, a.k.a. energy boost. While it is true that you can get increased energy levels, when the concentration of the drug in your blood reaches its peak concentration, its further lowering minimizes the euphoria.

It is worth mentioning that long-term use or increase in the dose of these anorectics for the sake of getting more energy is fraught with serious health deterioration and severe adverse events. If you think that you took too much of either Duromine or Phentermine HCl, you need to immediately seek medical help.

Keep in mind that you will get the best of beneficial Duromine/Phentermine effects, if you use the drugs alongside an efficient weight loss program (nutrition + activity + water + eliminate bad habits). If your weight loss is less than 5% of the initial body weight before the beginning of the course, further use of these drugs is unreasonable.

Duromine vs Phentermine: How to get

Due to the fact that both medicines are potent CNS stimulants with a long list of possible side effects and contraindications, as well as refer to the list of Controlled Substances, their purchase requires a prescription. Candidates that suit the criteria for Duromine/Phentermine prescription are obese people with a BMI higher than 30 kg/m2 or those, whose BMI is higher than 27 kg/m2 and suffering from such risk factors like:

  • increased lipids level,
  • moderately high and controlled blood pressure,
  • diabetes.

Due to the popularity and efficacy of these appetite suppressants, various shady ways were invented to get them without a prescription. However, it is important to remember that there is no legal way to buy Duromine online without a prescription.

Duromine vs Phentermine: Non-prescription alternatives

Both the side effects and the need to visit a doctor and get a prescription can hinder people’s decisiveness to begin the pharmacological therapy for weight loss. Modern pharmaceutical market has a wide offer for natural supplements that can provide multiple weight loss benefits without requiring a prescription.

Phen 375 is considered one of the safe and effective alternatives for Duromine and Phentermine. All natural, with a very short list of side effects, this weight loss supplement slowly but steadily conquers the weight loss industry. Learning more information about the difference between Duromine and Phen 375 can help you take an informed and reasonable choice.

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